Colivelin

Description

What is Colivelin?

Colivelin is a potent synthetic hybrid neuroprotective peptide engineered by fusing the core active sequence of activity-dependent neurotrophic factor (ADNF-9) with a derivative of humanin (AGA-HNG17), creating a dual-mechanism neuroprotectant with broader efficacy than either parent peptide. It was developed by Matsuoka and colleagues as a research tool for studying neuronal survival against multiple neurotoxic insults associated with Alzheimer’s disease. For published research, see PubMed studies on Colivelin{:target=“_blank” rel=“noopener”}.

Colivelin has demonstrated femtomolar-range neuroprotective activity in vitro, making it one of the most potent neuroprotective peptides described in the literature.

Best-Peptides supplies research-grade Colivelin with guaranteed ≥99% purity and full analytical documentation.

How Does Colivelin Work?

STAT3 Pathway Activation

• gp130/IL-27R engagement – Receptor complex activation
• JAK2 phosphorylation – Kinase cascade initiation
• STAT3 dimerisation – Transcription factor activation
• Pro-survival gene induction – Bcl-2 and Bcl-xL upregulation

Dual Neuroprotective Mechanism

• Humanin component – STAT3-mediated neuronal survival
• ADNF component – NF-κB-mediated protection
• Synergistic coverage – Protection against diverse insults
• Femtomolar potency – Ultra-high neuroprotective activity

Anti-Amyloid Protection

• Aβ₁₋₄₂ toxicity rescue – Amyloid-beta-mediated death prevention
• APP mutant protection – V642I-APP neuronal death blockade
• Presenilin rescue – M146L-PS1 toxicity attenuation
• Oxidative stress defence – ROS-mediated damage reduction

Research Applications

Alzheimer’s Disease Modelling

• Amyloid toxicity – Aβ oligomer challenge experiments
• Familial AD mutations – APP and presenilin mutant studies
• Cognitive rescue – In vivo memory impairment models

Neuroprotection Pharmacology

• Potency comparison – Colivelin vs humanin vs ADNF
• Pathway dissection – STAT3 vs NF-κB contribution analysis
• Dose-response profiling – Femtomolar to nanomolar range

Translational Neuroscience

• Blood-brain barrier studies – CNS delivery and penetration
• Biomarker analysis – Neuroprotection readout development
• Combination therapy – Multi-target neuroprotection strategies

Colivelin Specifications

Storage and Handling

Ordering Information

Minimum order: $200 | 10% discount on orders over $200

Research Use Statement

For laboratory research only. Not intended for human or veterinary use. Researchers should follow all applicable regulations.